Antimicrobial and Antibiofilm Biomaterials Strategies – RAPID FIRE
Timeslot: Wednesday, April 27, 2022 - 2:45pm to 3:45pm
Room: Harborside Ballroom A-B, 4th Floor
Treatment of microbial infections is complicated by rising antibiotic resistance and the inherent difficulty of treating biofilm-associated infections. In both scenarios, many current FDA approved antimicrobial drugs are ineffective, leading to a significant health and economic burden. Compounding these issues is a lack of development of new antimicrobial drug classes limiting the pipeline of available therapeutics. Advances in antimicrobial biomaterial therapies have the potential to improve outcomes for bacterial, fungal, viral, and biofilm-associated infections. Innovations in biomaterials are critically needed in the face of the COVID-19 pandemic, both for treatments of the SARS-CoV-2 virus, and also for effective treatment of the severe bacterial and fungal co-infections that have been reported. This session will cover biomaterials approaches to treat bacterial, fungal, and viral infections, including the prevention and eradication of biofilms. Strategies discussed may include antimicrobial surface modifications, device coatings, drug delivery, and immune engineering approaches.
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 47. Synthetic Mucus Hydrogels for the Delivery of Antimicrobial Peptides, Sydney Yang*, Gregg Duncan, PhD, University of Maryland, College Park, College Park, MD, USA
2:50:00 PM 48. Lysostaphin-delivering hydrogels for the promotion of bone healing and infection mitigation in a murine fem- oral fracture model, Jeremy Caplin(1)*, Julie Gordon(2), Pranav Kalelkar(1), Chris Johnson(1), Rodney Donlan(3), John Peroni(2), Andrés García(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)University of Georgia, Athens, GA, USA, (3)Centers for Disease Control and Prevention, Atlanta, GA, USA
2:55:00 PM 49. Smart bacterial hunting for wound healing, Malcolm Xing*, University of Manitoba, Winnipeg, MB, Canada
3:00:00 PM 50. Effect of Commercially Available Wound Irrigation Solutions on Unin- fected Host Tissue in a Murine Model, Dexter Powell, MD(1), Brendan Comer, MD.(1), Bin Wu, MD.(1), Paula Diets, MS.(1), Therese Bou-Akl, MD., PhD.(1,2), Wei-ping Ren, MD., PhD.(1,2)*, David Markel, MD.(1,2); (1)Ascension Providence Hospital, Southfield, MI, USA, (2)Wayne State University, Detroit, MI, USA
3:05:00 51. Loading a First-In-Class Antibiofilm Compound into Polyurethane Foam for Negative Pressure Wound Therapy, Tyler Smith(1)*, Kaden Rawson(1), Travis Newberger(1), Isaac Bell(1), Spencer Brown(1), Paul Sebahar, PhD(1,2), Ryan Looper, PhD(1,2), Paul Pasquina, MD(3,4), Brad Isaacson, PhD, MBA, MSF(3,5), John Shero, MHA(6), Dustin Williams, PhD(1,2); (1)University of Utah, Salt Lake City, UT, USA, (2)Curza Global, Salt Lake City, UT, USA, (3)Department of Physical Medicine and Rehabilitation, The Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, (4)Department of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA, (5)The Geneva Foundation, Tacoma, UT, USA, (6)DoD-VA Extremity Trauma and Amputation Center of Excellence, Joint Base San Antonio Fort Sam Houston, TX, USA
3:15:00PM 52. Modifying Ti Wires with Pep- toid-Loaded Microgels to Inhibit Intra-Operative OR Contamination, Wenhan Zhao(1)*, Matthew Libera(1), Annelise Barron(2), Haoyu Wang(1), Hongjun Wang(1), Lauren De Stefano(3), Jordan Katz(3), Jennifer Lin(2); (1)Stevens Institute of Technology, Hoboken, NJ, USA, (2)Stanford University, Stanford, CA, USA, (3)Orthobond Corporation, Monmouth Junction, NJ, USA
3:20:00 PM 53. Physiochemical and bactericidal activity evaluation: Silver-augmented 3D-printed scaffoldsâ€”An in vitro study, Vasudev Nayak, MSci(1,2)*, Nick Tovar, PhD, DDS(1), Jacques Hacque- bord, MD(3), Pablo Atria, DDS, MSci(1), Simone Duarte, DDS, PhD(4), Caroline Tonone, DDS(4), Beatriz Panariello, DDS, PhD(4), Paulo Coelho, DDS, PhD, MBA(1,2), Lukasz Witek, MSci, PhD(1,2); (1)NYU College of Dentistry, New York, NY, USA, (2)New York University Tandon School of Engineering, Brooklyn, NY, USA, (3)NYU Grossman School of Medicine, New York, NY, USA, (4)Indiana University School of Dentistry, Indianapolis, IN, USA
3:25:00 54. Cathodic Voltage-Controlled Electrical Stimulation of SS316L for Eradication of Methicillin-Resistant Staphylococcus aureus, Gowtham Mohanraj*, Menachem Tobias, Mark Ehrensberger, University at Buffalo, Buffalo, NY, USA
3:30:00 PM 55. Characterization of silanized titanium loaded with 2-heptylcyclopro- pane-1-carboxylic acid, Zoe Harrison, Josh Bush, PhD*, Felio Perez, PhD, Joel Bumgardner, PhD, Tomoko Fujiwara, PhD, Daniel Baker, PhD, Rachel Wiley, Jessica Jennings, PhD, University of Memphis, Memphis, TN, USA
3:35:00 56. Prevention of Staphylococcus aureus Biofilm Infections on Titanium Alloy Ti64 and Polyethylene Using Cathodic Voltage-Controlled Electrical Stimulation, Kevin McPhillips, M.S.*, Menachem Tobias, M.S., Mark Ehrensberger, PhD, University at Buffalo, Buffalo, NY, USA