Antimicrobial and Antibiofilm Biomaterials Strategies 2
Timeslot: Saturday, April 30, 2022 - 10:30am to 12:30pm
Room: Harborside Ballroom A-B, 4th Floor
Treatment of microbial infections is complicated by rising antibiotic resistance and the inherent difficulty of treating biofilm-associated infections. In both scenarios, many current FDA approved antimicrobial drugs are ineffective, leading to a significant health and economic burden. Compounding these issues is a lack of development of new antimicrobial drug classes limiting the pipeline of available therapeutics. Advances in antimicrobial biomaterial therapies have the potential to improve outcomes for bacterial, fungal, viral, and biofilm-associated infections. Innovations in biomaterials are critically needed in the face of the COVID-19 pandemic, both for treatments of the SARS-CoV-2 virus, and also for effective treatment of the severe bacterial and fungal co-infections that have been reported. This session will cover biomaterials approaches to treat bacterial, fungal, and viral infections, including the prevention and eradication of biofilms. Strategies discussed may include antimicrobial surface modifications, device coatings, drug delivery, and immune engineering approaches.
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 323. INVITED SPEAKER - Christopher A. Alabi, PhD, Cornell University
11:00:00 324. Prevention of Medical Device Infections via Multi-action Nitric Oxide and Chlorhexidine Diacetate Releasing Medical Grade Silicone Biointerfaces, Elizabeth Brisbois*, Manjyot Kaur Chug, Hamed Massoumi, University of Georgia, Athens, GA, USA
11:15:00 AM 325. Biphasic Dressings for Effective Treatment of Biofilms in Chronic Wounds, Jingwei Xie*, Yajuan Su, Guangshun Wang, University of Nebraska Medical Center, Omaha, NE, USA
11:30:00 AM 326. Enzymatically-Responsive Shape Memory Polymers for Infection Surveillance in Chronic Wounds, Maryam Ramezani, PhD*, Avery Gunderson, Mary Beth Monroe, PhD, Syracuse University, Syracuse, NY, USA
11:45:00 AM 327. Drug-Eluting Endotracheal Tubes for Microbiome Modulation in Murine Airway Models, Matthew Aronson(1,2)*, Ryan Friedman(1,2), Daniel Ghaderi(1,2), Riccardo Gottardi(1,2,3); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Children’s Hospital of Philadelphia, Philadelphia, PA, USA, (3)Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
12:00:00 PM 328. Oxygenating and antibacterial MACF hydrogel dressings reduce infection on an infected diabetic wound model, Hannah Durr*, Shahrzad Abri, MS, Nic Leipzig, PhD, University of Akron, Akron, OH, USA
12:15:00 PM 329. Lysostaphin-loaded hydrogels mitigate chronic S. aureus infection in non-union bone defects, Pranav Kalelkar, PhD*, Andres Garcia, PhD, Georgia Institute of Technology, Atlanta, GA, USA