Biomaterial-Based In Vitro Cancer/Tumor Models for Drug Screening and Diagnostics – RAPID FIRE
Timeslot: Wednesday, April 27, 2022 - 2:45pm to 3:45pm
Room: Dover A-C, 3rd Floor
Biomaterial-based in vitro cancer/tumor models offer a close mimic of the complex tumor microenvironment, providing versatile platforms for drug and toxicology screening as well as diagnostics. The implementation of these preclinical tools can afford low-cost, easy-to-use systems to evaluate cancer treatments, enhancing the efficacy and toxicological assessment for specific patients, mitigating the limitations of current technologies, and expanding the treatment options and patient’s quality of life.
Abstracts will be available for download on April 27, 2022.
2:45:00 67. HA Concentration-De- pendent Invasiveness of Patient-Derived Gliomaspheres Cultured in 3D Hydrogels, Gevick Safarians*, Itay Solomon, Alireza Sohrabi, Stephanie Seidlits, University of California, Los Angeles, Los Angeles, CA, USA
2:50:00 PM 68. PEG-Based Adaptable Hydrogels Elucidate the Role of Viscoelasticity in Modulating Glioblastoma Fates in 3D, Sauradeep Sinha(1)*, Manish Ayush- man(1), Xinming Tong(2), Sarah Jones(3), Gerald Grant, MD(4), Fan Yang, PhD(1,2); (1)Bioengineering, Stanford, CA, USA, (2)Orthopaedic Surgery, Palo Alto, CA, USA, (3)Chemistry, Stanford, CA, USA, (4)Neurosurgery, Palo Alto, CA, USA
2:55:00 PM 69. Breast Cancer Hydrogel Microspheres for High-Throughput Drug Screening, Yuan Tian, PhD(1), Shantanu Pradhan, PhD(1,2), Wen Seeto, PhD(1), Dmitriy Minond, PhD(3), Elizabeth Lipke, PhD(1)*; (1)Auburn University, Auburn, AL, USA, (2)Indian Institute of Tech- nology Madras, Chennai, India, (3)Nova Southeastern University, Fort Lauderdale, FL, USA
3:00:00 PM 70. Decellularized Intestine Extracellular Matrix-Em- bedded Within Colorectal Tumor Spheroids to Recapitulate the Tumor Microenvironment, Michael Buckenmeyer, PhD*, Elizabeth Brooks, PhD, Madison Taylor, BS, Matthew Wolf, PhD, National Cancer Institute (NIH), Frederick, MD, USA
3:05:00 PM 71. A 3D Viscoelastic Glioblastoma Model to Assess the Effects of Matrix Stiffness on Tumor Invasion and Drug Response, Sauradeep Sinha(1)*, Manish Ayushman(1), Xinming Tong(2), Sarah Jones(3), Gerald Grant, MD(4), Fan Yang, PhD(1,2); (1)Bioengineering, Stanford, CA, USA, (2)Orthopaedic Surgery, Palo Alto, CA, USA, (3)Chemistry, Stanford, CA, USA, (4)Neurosurgery, Palo Alto, CA, USA
3:15:00 PM 72. Hydrogel Arrays Enable Increased Throughput for Screening Therapeutic Re- sponses in 3D Tumor Models, Stephanie Seidlits, PhD*, Alireza Sohrabi, PhD, Mary Epperson, Laila Rad, BS, Mayilone Sathialingam, Jeremy Huang, Ze Zhong Wang, PhD, Jesse Liang, University of California Los Angeles, Los Angeles, CA, USA
3:20:00 PM 73. Enhanced Combinatorial Analysis of Tumor Cell- ECM Interactions Using Design-of-Experiment Optimized Microarrays, Hannah Kimmel*, Gregory Underhill, PhD, University of Illinois at Urbana-Cham- paign, Champaign, IL, USA
3:25:00 PM 74. Three-Dimensional Cancer-Immune Co-culture Model Using Lyophilized Silk Fibroin Scaffolds, Katelyn Mistretta, BS*, Jeannine Coburn, PhD, Worcester Polytechnic Institute, Worcester, MA, USA
3:30:00 PM 75. Fluorescence-dim- ming platforms for real-time monitoring of protease levels in tumor tissues, Miso Lee*, Oanh-Vu Pham-Nguyen, Wei Mao, Jaekeun Park, Wanho Cho, Hoai-Thuong Bui, Hyuksang Yoo, Kangwon National University, Chuncheon-si, Republic of Korea
3:35:00 PM 76. Colorectal Tumor Decellularization: Comparison of Three Detergent Based Methods, Madison Taylor*, Michael Buckenmeyer, PhD, Matthew Wolf, PhD, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA