Biomaterial Systems for Immunomodulation and Immune Cell Therapy – RAPID FIRE
Timeslot: Wednesday, April 27, 2022 - 2:45pm to 3:45pm
Room: Laurel A-B, 4th Floor
We have only recently begun to appreciate the immune system's ability to prevent and cure disease; however, unlocking its full potential to fight disease will require the implementation of biomaterial technologies. This session focuses on the use of biomaterial systems to enhance and direct the immune response for therapeutic or prophylactic gain. Example biomaterial innovations in this space include lymph node-targeting nanoparticles, intradermal microneedles, and scaffolds for engineered T cell expansion as well as drug and gene delivery vehicles that modulate the function of native immune cells.
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 57. Bone-targeted Nanoparticles Modulate Macrophage-mediated Fracture Healing, Baixue (Dorothy) Xiao, Yuchen Wang, Marian Ackun-Farmmer*, Danielle Benoit, University of Rochester, Rochester, NY, USA
2:50:00 PM 58. Basophils drive immune responses elicited by self-assem- bled peptide nanofiber vaccines, Yaoying Wu, PhD*, Hanning Wen, Benjamin Cossette, Lucas Shores, Tatiana Segura, Joel Col- lier, Duke University, Durham, NC, USA
2:55:00 59. Microparticle Artificial Antigen Presenting Cell Elasticity Influ- ences Activation of Antigen-Specific T cells, Savannah Est-Witte*, Sydney Shannon, Dennis Gong, Kaitlyn Calabresi, Jonathan Schneck, MD, PhD, Jordan Green, PhD, Johns Hopkins University, Baltimore, MD, USA
3:00:00 PM 60. Biomaterial Scaffolds as In Vivo CAR-T Cell Factories, Pritha Agarwalla, PhD(1), Edikan Ogun- naike, PhD(2), Fraces Ligler, PhD(1), Gianpietro Dotti, MD(2), Yevgeny Brudno(1)*; (1)Joint Department of Biomedical Engineering at UNC - Chapel Hill and NC State - Raleigh, Chapel Hill, NC, USA, (2)University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
3:05:00 PM 61. In Vivo Expansion of Endoge- nous Antigen-Specific CD8+ T cells using Artificial T-Cell Stimulating Microparticles, Natalie Livingston, B.S.*, John Hickey, PhD, Sebastian Salathe, B.S., Hai-Quan Mao, PhD, Jona- than Schneck, MD, PhD, Johns Hopkins University, Baltimore, MD, USA
3:15:00 PM 62. Nanoparticle-Mediated Chemoimmunotherapy Delivery to Lymph Nodes Unlocks Drug Synergies in TNBC, Margaret Manspeaker(1)*, Meghan O’Melia, PhD(1), Susan Thomas, PhD(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University School of Medicine, Atlanta, GA, USA
3:20:00 PM 63. Hydrogel Platforms to Support Tolerogenic Trophoblasts for Cell Therapy, Emily Slaby*, Jessica Weaver, PhD, Arizona State University, Tempe, AZ, USA
3:25:00 PM 64. Hydrolytically Degradable Microgels for Immune Cell Encapsulation, Ana Mora-Boza, PhD*, Valeria Juárez, Grad Stu- dent, Maria Coronel, PhD, Ankur Singh, Professor, Andrés García, Georgia Institute of Technology, Atlanta, GA, USA
3:30:00 PM 65. High Throughput Characteriza- tion of Lysosomotropic Polymer Adjuvants, Adam Weiss(1)*, Marcos Lopez, II(1), Saikat Manna(1), Sampa Maiti(2), Wenjun Du(2), Stuart Rowan(1), Aaron Esser-Kahn(1); (1)University of Chicago, Chicago, IL, USA, (2)Central Michigan University, Mount Pleasant, MI, USA
3:35:00 PM 66. Bifunctional biomaterial design to promote vessel formation and reduce macrophage activation, Aakanksha Jha*, Erika Moore, PhD, University of Florida, Gainesville, FL, USA