Biomaterials in Engineering the Tumor Immune Microenvironment
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Laurel C-D, 4th Floor
Malignant cells of the tumor co-exist with non-malignant cells in a 3D space, along with structural and secreted components. Immune cells of many types such as macrophages, dendritic cells, mast cells, T-cells and more make up the tumor immune microenvironment (TIME). Biomaterials are incorporated in bioengineering the TIME for multiple purposes: (1) creating bioengineered models to further fundamental immuno-oncology studies; and (2) modulating anti-tumor immune response. Cancer-immune cell interactions in the TIME are specifically important to study for the development of immunotherapies to treat various types of cancer. Not only is engineering the TIME useful for drug discovery, it can also provide mechanistic insights into cancer-immune cell interactions within the TIME that can be used to develop targeted immuno-therapies. In this session, we will explore all aspects of biomaterials used to engineer the tumor immune microenvironment.
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 19. INVITED SPEAKER: Biomaterials to model and manipulate the tumor microenvironment, Jennifer H. Elisseeff, PhD, Johns Hopkins University
1:30:00 PM 20. CD4 T cell Signal in Lymph Nodes Attenuate Response to Single and Dual B Cell Receptor Inhibitors in Lymphomas, Grazia Marsico, PhD(1)*, Karen Martin, BSc(1), Andrés García, PhD(1), Jean Koff, MD(2), Ankur Singh, Ph.D(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, Georgia, USA
1:45:00 PM 21. Engineered Models of Macrophage-Mediated Ovarian Cancer Liver Metastasis to Evaluate Nano-Immunotherapies, Sabrina VandenHeuvel(1)*, Heather Farris(1), Eric Chau(2), Biana Godin, PhD(1,2), Shreya Raghavan, PhD(1,2); (1)Texas A&M University, College Station, TX, USA, (2)Houston Methodist Research Institute, Houston, TX, USA
2:00:00PM 22. Localized Repolarization of Tumor-Associated Macrophages via Cytokine-Loaded, Injectable Cryogels, Evan Glass(1), Sydney Henriques(1)*, Sohini Roy, PhD(2), Abigail Manning(1), Benjamin Hacker(1), Christopher Haycook, PhD(1), Marjan Rafat, PhD(1), Young Kim, MD, PhD(2), Todd Giorgio, PhD(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Vanderbilt University Medical Center, Nashville, TN, USA
2:15:00 PM 23. Rewiring the Tumor Immune Microenvironment via Immunomodulatory Injectable Nanoparticle-Based Hydrogels, Santiago Correa, PhD*, Juliana Idoyaga, PhD, Eric Appel, PhD, Stanford, Stanford, CA, USA