Biomaterials for Organoids

Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Essex A-C, 4th Floor

About

Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. Organoids bridge a gap in existing model systems by providing a more stable system amenable to extended cultivation and manipulation while more representative of in vivo physiology. This session will cover the most recent advancements of biomaterials-mediated organoid and tissue chip technologies in regenerative medicine, cancer therapy, drug testing, environmental control, monitoring, adaptive sensing, and translational applications. This topic was well-received in the 2021 SFB meeting and is an exciting emerging research area. In 2022, we will continue this session and promote translational research to biomaterials-mediated organoid projects' commercial viability.

Abstracts

Abstracts will be available for download on April 27, 2022.

  • 1:00:00 PM 168. Tissue-Engineered Blood-Brain Barrier Model to Study Dys- functional Effects of Oxidative Stress, Tracy Chung*, Raleigh Linville, PhD, Zhaobin Guo, PhD, Robert Ye, Ria Jha, Peter Searson, PhD, Johns Hopkins University, Baltimore, MD, USA

  • 1:15:00 PM 169. In Situ Super-Resolution Imaging of Organoids and Extracellular Matrix Interactions via Photo- expansion Microsco- py, Michael Blatchley, PhD(1)*, Arda Günay, PhD(1), Max Yavitt(1), Elijah Hawat(1), Peter Dempsey, PhD(2), Kristi Anseth, PhD(1); (1)University of Colorado - Boulder, Boulder, CO, USA, (2)University of Colorado School of Medicine, Aurora, CO, USA

  • 1:30:00 PM 170. Pancreatic organogenesis in PEG-based synthetic hydrogels, Matthew Arkenberg, MS(1)*, Chien- Chi Lin, PhD(2); (1)Purdue University, West Lafayette, IN, USA, (2)Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

  • 1:45:00 PM 171. Aged B Cell Immune Organoid to Study Antigen and Ajuvant Efficacy, Zhe Zhong(1)*, Ankur Singh(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA

  • 2:00:00 PM 172. A Biofunctionalized Hydrogel Improves Representative Features of Cortical Brain Organoid Models, Kylie Balotin*, Lauren Drake, Neelansh Bute, Allison Bosworth, PhD, Brian O’Grady, PhD, Ethan Lippmann, PhD, Vanderbilt University, Nashville, TN, USA

  • 2:15:00 PM 173. Establish Structure-Function Correlation for Geometrically Templated Cardiac Organoids Using Artificial Intelligence, Plansky Hoang, Andrew Kowalczewski, Shiyang Sun, Zhen Ma*, Syracuse University, Syracuse, NY, USA