Biomaterials for Pancreatic Islet Replacement and Immune Tolerance in T1D-1

Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Harborside Ballroom D-E, 4th Floor


The advent of new sources of beta cells, including from stem cells, has greatly advanced the potential of beta cell replacement as a functional cure for type 1 diabetes and some forms of type 2 diabetes. A major barrier that remains to be solved is blocking or modulating immune effectors while simultaneously promoting islet survival and function. Biomaterials play a central role in addressing this challenge, as vehicles for islet delivery, as microenvironments supportive of islet function, and as sites of immune modulation.


Abstracts will be available for download on April 27, 2022.

  • 11:30:00 AM 257. Delivery of Dissociated Islets Cells within Micro- porous Annealed Particle Scaffold to Treat T1D, Colleen Roosa*, Mingyang Ma, Preeti Chhabra, PhD, Kenneth Brayman, PhD, MD, Donald Griffin, PhD, University of Virginia, Charlottesville, VA, USA

  • 11:45:00 AM 258. . Parallel Evaluation of Polyethylene Glycol Conformal Coating and Alginate Encapsulation as Immunoisolation Strat- egies for Pancreatic Islet Transplantation, Teresa De Toni(1,2)*, Aaron Stock(1,2), Peter Buchwald(1,3), Alice Tomei(1,2); (1)Diabetes Re- search Institute, Miami, FL, USA, (2)Department of Biomedical Engineering, Coral Gables, FL, USA, (3)Department of Molecular and Cellular Pharmacology, Miami, FL, USA

  • 12:00:00 PM 259. Biomimetic Scaffolds with Controlled Microarchitec- ture Enhance Beta Cell Viability and Function for the Treatment of Type 1 Diabetes, Bhushan Kharbikar, PhD*, Sudipta Ashe, PhD, Qizhi Tang, PhD, Matthias Hebrok, PhD, Tejal Desai, PhD, University of California San Francisco, San Francisco, CA, USA

  • 12:15:00 PM 260. Efficacy of VEGF-deliver- ing hydrogel to promote vascularization in the porcine subcutaneous space, Michelle Quizon, BS(1)*, Juline Deppen(2), Rebecca Levit(2), Andres Garcia(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA