Biomaterials for Pancreatic Islet Replacement and Immune Tolerance in T1D-2

Timeslot: Saturday, April 30, 2022 - 10:30am to 12:30pm
Room: Kent A-C, 4th Floor


The advent of new sources of beta cells, including from stem cells, has greatly advanced the potential of beta cell replacement as a functional cure for type 1 diabetes and some forms of type 2 diabetes. A major barrier that remains to be solved is blocking or modulating immune effectors while simultaneously promoting islet survival and function. Biomaterials play a central role in addressing this challenge, as vehicles for islet delivery, as microenvironments supportive of islet function, and as sites of immune modulation.


Abstracts will be available for download on April 27, 2022.

  • 10:30:00 AM 330. INVITED SPEAKER - Cellular engineering to produce replace- ment islets for diabetes cellular therapy, Jeffrey Millman, PhD, Washington University School of Medicine

  • 11:00:00 AM 331. Injectable PEG-MAL Hydrogel Based on Guest-Host Interlinked PEG Microgels, Adrienne Widener*, Jorge Santini-Gon- zalez, Conor Given, Thomas Angelini, PhD, Edward Phelps, PhD, University of Florida, Gainesville, FL, USA

  • 11:15:00 AM 332. Synthetic Hydrogel-mediated Maturation and Engraftment of Human Pluripotent Stem Cell-derived Beta Cells, Michael Hunckler*, Maria Coronel, Adriana Mulero-Russe, Andrés García, Georgia Institute of Technology, Atlanta, GA, USA

  • 11:30:00 333. In Vitro Hydrogel Platform for the Interrogation of the Role of Chemokines in Human T1D Immunopathology, Magdalena Samojlik, MS(1)*, Ying Li, PhD(1,2), Smit Patel(1), Aidan Fernandez(1), Todd Brusko, PhD(2), Clayton Mathews, PhD(2), Edward Phelps, PhD(1), Cherie Stabler, PhD(1); (1)University of Florida, College of Engineering, Gainesville, FL, USA, (2)University of Florida, College of Medicine, Gainesville, FL, USA

  • 11:45:00 AM 334. CCL21 and Beta Cell Antigen Hydrogel Platform for Induction of Antigen-Specific Tolerance in Type 1 Diabetes, Flavia Zisi Tegou, MS(1,2)*, Diana Velluto, PhD(2), Aaron Stock, PhD(1,2), Silviya Zustiak, PhD(3), Alice Tomei, PhD(1,2); (1)University of Miami, Coral Gables, FL, USA, (2)Diabetes Research Institute, Miami, FL, USA, (3)Saint Louis University, Saint Louis, MO, USA

  • 12:00:00 PM 335. Microporous Scaffolds for Culture and Transplantation of Stem Cell Derived Beta-Cells, Kelly Crumley*, Elizabeth Bealer, Feiran Li, Daniel Clough, PhD, Lonnie Shea, PhD, University of Michigan, Ann Arbor, MI, USA

  • 12:15:00 PM 336. In Vivo pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core, Mrignayani Kotecha(1)*, Navin Viswakarma(1), Eliyas Siddiqui(1), Safa Hameed(1), Sonny Patel(1), Longhai Wang(2), Alexander Ulrich Ernst(2), Minglin Ma(2), Cherie Stabler(3), Boris Epel(1,4); (1)O2M Technologies, LLC, Chicago, IN, USA, (2)Cornell University, Ithaca, NY, USA, (3)University of Florida, Gainesville, FL, USA, (4)The University of Chicago, Chicago, IL, USA

Invited Speaker(s)