Biophysical Strategies for Regulation of Cellular Microenvironments

Timeslot: Saturday, April 30, 2022 - 10:30am to 12:30pm
Room: Laurel A-B, 4th Floor


Biophysical factors directed by biomaterials are known to play important roles in regulating cellular behavior by influencing gene and protein expression, protein localization, and cell signaling activity. This session focuses on biomaterial-based strategies for regulating biophysical factors in engineered cellular microenvironments. Topics include but are not limited to novel uses of biomaterials for regulation of nano- and micro-topographical and ligand patterning cues, normal and shear stress environments, thermosensitive properties, and physical parameters of fiber networks for regulating cellular phenotype. This includes studies incorporating novel strategies for control of biophysical parameters in biomaterial design for engineering of physiological models as well as fundamental studies of the mechanisms by which cells utilize biophysical cues from the biomaterials in their microenvironment to elicit specific biological outcomes. The studies presented in this session will contribute to the design of next-generation biomaterials capable of precisely and predictably directing cellular behaviors.


Abstracts will be available for download on April 27, 2022.

  • 10:30:00 AM 337. Extracellular Matrix in Hydrogel-based Organoids Regulate Epigenetics and Signaling in Prostate Cancers, Ankur Singh(1)*, Matthew Mosquera(2), Ahmet Coskun(1), Zhou Fang(1), Shuangyi Cai(1), Sungwoong Kim(1), Olivier Elemento(3); (1)Georgia Insti- tute of Technology, Atlanta, GA, USA, (2)Cornell University, Ithaca, NY, USA, (3)Weill Cornell Medicine, New York, NY, USA

  • 10:45:00 AM 338. Influence of Interpenetrating Network Viscoelasticity on Cellular Infiltration, Karen Xu*, Jason Burdick, PhD, University of Pennsylvania, Philadelphia, PA, USA

  • 11:00:00 AM 339. Synthetic semi-IPN hydrogels with fast stress-relaxation to probe stromal-cancer interactions, Fang-Yi Lin, PhD, Chien-Chi Lin, PhD*, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

  • 11:15:00 AM 340. Biomimetic Proteoglycans Augment the Cellular Microniche of Chondrocytes in Articular Cartilage, Elizabeth Kahle(1)*, Biao Han, PhD(1), Prashant Chandrasekaran, PhD(1), Evan Phillips, PhD(1), Katsiaryna Prudnikova, PhD(1), Lin Han, PhD(1), Michele Marcolongo, PhD, PE(1,2); (1)Drexel Uni- versity, Philadelphia, PA, USA, (2)Villanova University, Villanova, PA, USA

  • 11:30:00 AM 341. Stretchable Collagen I Hydrogels Reverse Pro-Fibrotic Transcriptome of Senescent Fibroblasts, Jason Guo, PhD*, Michelle Griffin, MD, PhD, Nicholas Guardino, BS, Kellen Chen, PhD, Geoffrey Gurtner, MD, FACS, Michael Longaker, MD, MBA, FACS, Stanford University School of Medicine, Stanford, CA, USA

  • 11:45:00 AM 342. Cell-Mimetic Substrates Reprogram Collective Cell Behaviors, Elena Cho, Kevin Suh, Isaac Breinyn, Daniel Cohen, PhD*, Princeton University, Princeton, NJ, USA

  • 12:00:00 PM 343. Photopatterning Facilitates Deterministic Crypt Formation in iPSC-Derived Intestinal Organoids, Michael Blatchley, PhD(1)*, Max Yavitt(1), Jasmine LeFevre(1), Patrick McGrath, PhD(2), Peter Dempsey, PhD(2), Kristi Anseth, PhD(1); (1)University of Colorado - Boulder, Boulder, CO, USA, (2)University of Colorado School of Medicine, Aurora, CO, USA

  • 12:15:00 PM 344. Modeling Acoustic Radiation Forces in Hydrogels using 3D Force Microscopy, Kevin Grassie(1,2)*, Hanna Anderson(1,2), Fayekah Assanah, PhD(1), Will Linthicum, PhD(1), Bryan Huey, PhD(1), Yusuf Khan, PhD(1,2); (1)University of Connecticut, Storrs, CT, USA, (2)UConn Health, Farmington, CT, USA