Drug Delivery 3 (SIG)

Timeslot: Saturday, April 30, 2022 - 10:30am to 12:30pm
Room: Harborside Ballroom D-E, 4th Floor

About

The Drug Delivery SIG session will consider abstracts that fall with the broad areas of therapeutic development, formulation, and application testing. Drug delivery from medical devices, tissue engineering scaffolds/hydrogels, films, microparticles, nanoparticles, environmentally responsive materials, and other types of biomaterial assemblies are all invited. Studies testing drug targeting, drug combinations, and drug/cell combinations are all also welcomed to submit. Drug delivery application areas of interest include but are not limited to regenerative medicine/tissue engineering, cell and tissue transplant, cardiovascular stents and other devices, cancer, microbial infection, and autoimmune diseases.

Abstracts

Abstracts will be available for download on April 27, 2022.

  • 10:30:00 AM 345. Biodegradable Nanogels for Controlled Release of Artemisinin-de- rived Drug to Treat Leukemia, Noha Ghonim(1)*, Sumiya Tabassum(2), Bryan Mott(3), Rena Lapidus(4), Michelle Rudek(5), Curt Civin(4), Tao Lowe(1); (1)School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA, (2)Health Sciences Facility II , University of Maryland Baltimore, Baltimore, MD, USA, (3)Wake Forest Baptist Medical Center, Winston-Salem, NC, USA, (4)School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA, (5)School of Medicine, Johns Hopkins University, Baltimore, MD, USA

  • 10:45:00 AM 346. Hydroxycholesterol Substitution in Ionizable Lipid Nanoparticles for mRNA Delivery to T Cells, Savan Patel*, Margaret Billingsley, Caitlin Frazee, Xuexiang Han, PhD, Kelsey Swingle, Michael Mitchell, PhD, University of Pennsylvania, Philadelphia, PA, USA

  • 11:00:00 AM 347. Multi-step Screening and Composition Optimization of Lipid Nanoparticles for Liver-targeted Plasmid DNA Delivery, Yining Zhu(1)*, Ruochen Shen(1), Ivan Vuong(1), Hai-Quan Mao, PhD(1), Rebekah Reynolds, PhD(2), Melanie Shears, PhD(2), Sean Murphy, PhD(2); (1)Johns Hopkins University, Baltimore, MD, USA, (2)University of Washington, Seattle, WA, USA

  • 11:15:00 AM 348. Engineering nanoparticle surface chemistry to maximize lymph node delivery via lymphatic vessels, Jacob McCright*, Colin Skeen, Jenny Yarmovsky, Katharina Maisel, University of Maryland, College Park, MD, USA

  • 11:30:00 AM 349. Biomimetic Membrane-Wrapped Nanoparticles for Targeted Drug Delivery to Hematopoietic Stem and Progenitor Cells, Jenna Harris(1)*, Emily Day(1,2); (1)University of Delaware, Newark, DE, USA, (2)Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA

  • 11:45:00 AM 350. Design, characterization, and modeling of a chitosan microneedle patch for transdermal delivery of meloxicam as a pain management strategy for use in cattle, Katherine Miranda Munoz*, David Castilla Casadiego, PhD, Jeremy Powell, PhD, Jorge Almodovar, PhD, University of Arkansas, Fayetteville, AR, USA

  • 12:00:00 PM 351. Mineral Coated Microparticles for Stabilization of Therapeutic Messenger RNA, Joshua Choe, MS*, William Murphy, PhD, University of Wisconsin - Madison, Madison, WI, USA

  • 12:15:00 PM 352. Continuous Manufacturing of Liposomes and Lipid-based Nanoparticles, Antonio Costa, PhD.(1)*, Xiaoming Xu(2), Gowtham Yenduri(3), Thomas O’Connor(2), Hailing Zhang(2), Diane Burgess(3); (1)DIANT PHARMA INC., Storrs, CT, USA, (2)FDA, Silver Spring, MD, USA, (3)University of Connecticut, Storrs, CT, USA