11:30:00 269. Fibrin-Specific pNIPAM Nanogels for Targeted Delivery of Fibrino- lytics and Anticoagulants to Treat Thrombotic Complications, Ana Sheridan(1,2)*, Nina Moiseiwitsch(1,2), Emily Mihalko, PhD(1,2), Kimberly Nellenbach, PhD(1,2), Manasi Krishnakumar(1,2), Abhichart Krissanaprasit, PhD(1), Joshua Degennaro(1,2), Jennifer Sollinger(1,2), Jerrold Levy, MD,FAHA,FCCE(3), Brian Cooley, PhD(2), Thom LaBean, PhD(1), Ashley Brown, PhD(1,2); (1)North Carolina State University, Raleigh, NC, USA, (2)University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, (3)Duke University, Durham, NC, USA

11:45:00 PM 270. An Adventitial Painting Modality of Local Drug Delivery to Abate Intimal Hyperplasia, Nisakorn Yodsanit(1,2)*, Takuro Shirasu, MD, PhD(3), Xiujie Xie, MD, PhD(3), Yuyuan Wang, PhD(1,2), Ruosen XIe, PhD(1,2), Yitao Huang(3), Bowen Wang, PhD(3), Lian-Wang Guo(3), K. Kent, MD(3), Shaoqin Gong, PhD(1,2); (1)University of Wisconsin-Madison, Madison, WI, USA, (2)Wisconsin Institute for Discovery, Madison, WI, USA, (3)University of Virginia, Charlottesville, VA, USA

12:00:00 PM 271. nterpenetrating Network Hydrogels for Enhanced Cardiac Retention of Extracellular Vesicles, Selen Uman(1)*, Mark Helmers, MD(2), Noah Weingarten, MD(2), Alexis Schiazza(2), Danika Meldrum(2), Sara Guevara-Plunkett(2), Pavan Atluri, MD(2), Jason Burdick, PhD(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Perelman School of Medicine, Philadelphia, PA, USA

12:15:00 PM 272. Poly[I:C] loaded Liposomes for Pulmonary Arterial Hypertension Treatment, Vidit Singh(1)*, Hu Yang, Laszlo Farkas(2), Hongliang He(3), Jawahar Khetan(1), Da Huang(1), Natalie Hall(1), Lavanya Bhargava(1); (1)Linda and Bipin Doshi Department of Chemical & Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, USA, (2)Department of Internal Medicine Division of Pulmonary, Critical Care and Sleep Medicine Davis Heart & Lung Research Institute, Ohio State University, Columbus, OH, USA, (3)Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA