Engineering Cells and Their Microenvironments 1 (SIG)

Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Harborside Ballroom D-E, 4th Floor


The Engineering Cells & Their Microenvironments Special Interest Group focuses on approaches to alter cell microenvironments. These approaches can be used to control biomaterial-induced cell signaling to enable stem cell manufacturing and differentiation, immunoengineering, as well as for the development of biomaterials for cell-based detection and diagnosis. These biomaterial-based approaches can also be utilized to direct cellular responses (e.g., proliferation, differentiation, morphological regulation, motility, matrix production) without the addition of external growth factors, chemicals, or drugs, thereby mitigating potential side-effects and facilitating improved in vitro and in vivo cellular outcomes. This session will focus on translation of these techniques toward a variety of specific applications ranging from, but not limited to, tissue engineering for dynamic disease models and regenerative medicine to therapeutics and direction of stem cell differentiation. Studies that develop biomimetic materials which provide specific physicochemical cues (e.g., composition, topography, stiffness) to achieve a desired cellular response will also be highlighted.


Abstracts will be available for download on April 27, 2022.

  • 2:45:00 PM 237. Engineered Matrices with Dynamic Crosslinks as a Viscoelastic Matrix for Human Neural Progenitor Cells, Michelle Huang*, Julien Roth, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA

  • 3:00:00 PM 238. Hypertrophic Cardiomyopathy Asso- ciated MYBPC3 Mutations Sensitize iPSC-Derived Micro-Heart Muscle to Mechanical Loading, Jingxuan Guo*, MS, David Schuftan, Nathaniel Huebsch, PhD, Washington Universi- ty in Saint Louis, St. Louis, MO, USA

  • 3:15:00 PM 239. ECM protein -decorated micro- particles to maintain cell survival and liver-specific function, Mona Mansouri, PhD*, William Imes, BS, Nic Leipzig, PhD, The University of Akron, Akron, OH, USA

  • 3:30:00 PM 240. Porous bio-click microgel scaffolds to study and control the osteoporotic mesenchymal stromal cell secretory profile, Varsha Rao(1,2)*, Emily Cravens(3), Marissa Wechsler, PhD(4), Samantha Wojda, PhD(3), Kristi Anseth, PhD(1,2), Seth Donahue, PhD(3); (1)University of Colorado Boulder, Boulder, CO, USA, (2)Biofrontiers Institute, Boulder, CO, USA, (3)University of Massachusetts Amherst, Amherst, MA, USA, (4)University of Texas San Antonio, San Antonio, TX, USA

  • 3:45:00 PM 241. A Biomaterial-based Stroma-free Synthetic Germinal Center: Using Lipid Membrane-Based Antigen Presentation as artificial FDCs and microbead-based CD40L as artificial TFH cells for efficient B cell signaling, Liana Kramer, MS(1,2)*, Hannah Song, PhD(1), Kaiya Mitchell(1), Mythili Kartik(1), Ankur Singh, PhD(1,2), Krishnendu Roy, PhD(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA

  • 4:00:00 PM 242. Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype, Daniel Chester, PhD, Veronica Lee, Paul Wagner, Matthew Nordberg, Matthew Fisher, PhD, Ashley Brown, PhD*, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, NC, USA

  • 4:15:00 PM 243. Stiffening viscoelastic hydrogels to investigate fibroblast activation and chromatin organization, Jenna Sumey*, Abigail Harrell, Steven Caliari, University of Virginia, Charlot- tesville, VA, USA

  • 4:30:00 PM 244. Incorporation of human extracel- lular matrix into hybrid-hydrogel models of fibrosis, Rukshika Hewa- wasam, PhD*, Predrag Serbedzija, PhD, Chelsea Magin, PhD, University of Colorado, Denver

  • Anschutz Medi- cal Campus, Aurora, CO, USA