Engineering Cells and Their Microenvironments 2 (SIG)
Timeslot: Saturday, April 30, 2022 - 10:30am to 12:30pm
Room: Essex A-C, 4th Floor
The Engineering Cells & Their Microenvironments Special Interest Group focuses on approaches to alter cell microenvironments. These approaches can be used to control biomaterial-induced cell signaling to enable stem cell manufacturing and differentiation, immunoengineering, as well as for the development of biomaterials for cell-based detection and diagnosis. These biomaterial-based approaches can also be utilized to direct cellular responses (e.g., proliferation, differentiation, morphological regulation, motility, matrix production) without the addition of external growth factors, chemicals, or drugs, thereby mitigating potential side-effects and facilitating improved in vitro and in vivo cellular outcomes. This session will focus on translation of these techniques toward a variety of specific applications ranging from, but not limited to, tissue engineering for dynamic disease models and regenerative medicine to therapeutics and direction of stem cell differentiation. Studies that develop biomimetic materials which provide specific physicochemical cues (e.g., composition, topography, stiffness) to achieve a desired cellular response will also be highlighted.
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 353. Multi-Modular Vascularized Bone Construct Comprised of Cell-Laden Microtissues, Nicholas Schott, MEng*, Jan Stegemann, PhD, The University of Michigan, Ann Arbor, MI, USA
10:45:00 AM 354. Gradient hydrogels formed by tandem diffusion and orthogonal click reactions, Chun-Yi Chang(1)*, Chien-Chi Lin(1,2); (1)Purdue University, West Lafayette, IN, USA, (2)Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA
11:00:00 AM 355. Silk Fibroin Hydrogels Mimic Native Matrix Mechanics and Support Salivary Spheroid Development, Eugenia Morales Carrillo(1)*, Solaleh Miar(1), Chih-ko Yeh(2), Joo Ong(1), Teja Guda(1); (1)The University of Texas at San Antonio, San Antonio, TX, USA, (2)University of Texas Health San Antonio, San Antonio, TX, USA
11:15:00 AM 356. Hydrogel Assisted Double Molding of 3D Print Enable Prestress Regulation of Stem Cell Derived Micro Heart Muscle, Daniel Simmons(1)*, David Schuftan(1), Jingxuan Guo(1), Kasoorelope Oguntuyo(1), Ghiska Ramahdita(1), Mary Munsell(1), Evan Miller(2), Nathaniel Huebsch(1); (1)Washington University in St. Louis, St. Louis, MO, USA, (2)University of California, Berkeley, University of California Berkeley, CA, USA
11:30:00 AM 357. Substrate Stiffness Regulates Fibronectin Matrix Microarchitecture During Wound Healing, Jennifer Patten, MS*, Gobind Singh, BS, Karin Wang, PhD, Temple University, Philadelphia, PA, USA
11:45:00 AM 358. Engineering symmetry breaking of single cells in three-dimensional matrices to direct stem cell fate, Ik Sung Cho*, Sing-Wan Wong, Stephen Lenzini, Jae-Won Shin, University of Illinois at Chicago, Chicago, IL, USA
12:00:00 PM 359. A Multi Fluorophore Reporter System for Identification and Quantification of Vomocytosis, Noah Pacifici*, Jamal Lewis, PhD, University of California, Davis, Davis, CA, USA
12:15:00 PM 360. Lentiviral reporters for temporal characterization of cell activation in response to dynamic stimuli, Samantha Cassel*, April Kloxin, PhD, University of Delaware, Newark, DE, USA