10:30:00 AM 361. Exogenous Delivery of Indoleamine 2,3-Dioxy- genase Reverses Disease Severity in Psoriasis, Sabrina Macias*, Arun Wanchoo, PhD, Gregory Hudalla, PhD, Benjamin Keselowsky, PhD, University of Florida, Gainesville, FL, USA

10:45:00 AM 362. Pro-fibrotic biomaterials implanted after injury skew local and systemic monocyte expression profiles, Joshua Hooks, PhD*, Kavita Krishnan, Patricia Mensah, Christopher Cherry, PhD, Jin Han, PhD, Jennifer Elisseeff, PhD, Johns Hopkins School of Medicine, Baltimore, MD, USA

11:00:00 AM 363. Using high-throughput ELISA protocols to identify seroconversion in adults during the COVID-19 Pandemic, Mondreakest Faust, BS*, Kaitlyn Sadtler, PhD, Maria Karkanitsa, BS, Jacquelyn Spathies, Heather Kalish, NIH (National Institutes for the Health), Bethesda, MD, USA

11:15:00 AM 364. Age-related Immune-Stromal Networks Inhibit Response to Regenerative Immunotherapies, Jin Han, PhD*, Christopher Cherry, PhD, Anna Ruta, B.S., David Maestas, B.S., Joscelyn Mejias, PhD, Helen Hieu Nguyen, B.S., Elana Fertig, PhD, Franck Housseau, PhD, Drew Pardoll, PhD, Jennifer Elisseeff, PhD, Johns Hopkins University, Baltimore, MD, USA

11:30:00 AM 365. Compositional Optimization of Lipid Nanoparticles to Transfect Antigen-Presenting Cells with mRNA In Vivo for Cancer Immunotherapy, Ivan Vuong*, Yining Zhu, Ruochen Shen, Won June Cho, Hai-Quan Mao, Johns Hopkins University, Baltimore, MD, USA

11:45:00 AM 366. Self assembling nanomaterials as defined active immunotherapies against IL1-β-mediated inflammation, Shamitha Shetty, MS*, Yaoying Wu, PhD, Joel Collier, PhD, Duke University, Durham, NC, USA

12:00:00 PM 367. Biodegradable Ionizable Polyesters as Non-Viral Gene Delivery Carriers for Enhanced Transfection of Immune Cells, Atanu Chakraborty, PhD*, Ryan Pearson, PhD, University of Maryland Baltimore, Baltimore, MD, USA

12:15:00 PM 368. PEGylation of Indoleamine 2,3-Dioxygenase for Systemic Immune Regulation, Jennifer Simonovich(1)*, Alexander Kwiatkowski(1), Arun Wanchoo(1), Dorina Avram(2), Benjamin Keselowsky(1); (1)University of Florida, Gainesville, FL, USA, (2)Moffitt Cancer Center, Tampa, FL, USA