Smart Biomaterials for Drug Delivery
Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Kent A-C, 4th Floor
Smart biomaterials (i.e., targeted and/or stimuli-responsive) have great potential for efficient delivery of therapeutics, increasing therapeutic activity, while avoiding biological barriers and decreasing toxicity and other adverse effects like drug resistance. Both endogenous and exogeneous stimuli have been utilized to trigger stimuli-responsive materials including pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. Similarly, many targeting mechanisms ranging from passive (e.g., enhanced permeation and retention) to active targeting approaches (e.g., antibody, nucleic acid, peptide ligand functionalization) have been integrated into targeted drug delivery systems. This session will focus on the development and use of such materials for applications including, but not limited to, cancer, and infectious, orthopedic, ophthalmic, and autoimmune diseases.
Abstracts will be available for download on April 27, 2022.
1:30:00 PM 308. INVITED SPEAKER: Engineering Immunity Using Biomaterials, Natalie Artzi, PhD, Harvard University
2:00:00 PM 309. Light-Activatable Ethanol Injection for the Treatment of Locally Unresectable Tumors, Chen-Hua Ma*, Jeffrey Yang, Huang- Chiao Huang, Jenna Mueller, University of Maryland, College Park, MD, USA
2:15:00 PM 310. Tumor Responsive and Tunable Polymeric Platform to Treat Glioblastoma, Elizabeth Gurysh, PhD*, Kathryn Moore, PhD, Allison Schorzman, PhD, Taek Lee, William Zamboni, PhD, Eric Bachelder, PhD, Shawn Hingtgen, PhD, Kristy Ainslie, PhD, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
2:30:00 PM 311. Noninvasive Refilling of Biomaterial Drug-Eluting Depots, Yevgeny Brudno*, PhD, Christopher Moody, Sharda Pandit, Sandeep Palvai, PhD, Joint Department of Biomedical Engineering at UNC - Chapel Hill and NC State - Raleigh, Raleigh, NC, USA
2:45:00 PM 312. Development of Antibody/siRNA Nanocarriers to Target Wnt Signaling in Triple-Negative Breast Cancer, Megan Dang(1)*, Sejal Suri(1), Carolina Gomez Casas(1), Rachel Riley, PhD(2), Emily Day, PhD(1); (1)University of Delaware, Newark, DE, USA, (2)Rowan University, Glassboro, NJ, USA
3:00:00 PM 313. Host-Guest Supramolecular Recognition in Hydrogel Drug Delivery, Matthew Webber, PhD*, University of Notre Dame, Notre Dame, IN, USA
3:15:00 PM 314. Protease-responsive drug delivery in a chemically-induced mouse model of subcutaneous inflammation, Dang Nguyen, PhD*, Thi Hong Anh Truong, PhD, Tram Dang, PhD, Nanyang Technological University, Singapore, Singapore