Stimuli-Responsive Materials for Tissue Engineering and Regenerative Medicine

Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Dover A-C, 3rd Floor


Stimuli-responsive materials allow for localized on-demand manipulation of the cellular microenvironment, providing unique opportunities to control cell behavior and fate. These responsive material systems have shown promise for applications in tissue engineering and regenerative medicine by enabling spatiotemporally-controlled presentation of mechanical properties, chemical cues, and other microenvironmental features. A variety of triggering stimuli, both exogenous and endogenous, have been explored to control these materials including light, ultrasound, electrical stimulation, and magnetic fields, as well as temperature, pH, and various chemical stimuli. This session will highlight recent advances in the development of stimuli-responsive materials for application in tissue engineering and regeneration, including, but not limited to, scaffolds for stem cell control, materials for guiding tissue development, dynamic "4D-patterned" materials, in vitro tissue/disease models, "smart" implantable scaffolds, and stimuli-responsive drug delivery platforms.


Abstracts will be available for download on April 27, 2022.

  • 1:00:00 PM 41. Tissues as Electrically Responsive and Programmable Biomaterials, Gawoon Shim, MSE, Isaac Breinyn, Avi Wolf, Daniel Cohen, PhD*; Princeton University, Princeton, NJ, USA

  • 1:15:00 PM 42. Reversible Intracellular Hydrogelation to Induce Macromolecular Crowding and Control Cell Cycle Behavior, Laura Macdougall*, Timothy Hoffman, Bruce Kirkpatrick, Benjamin Fairbanks, Christopher Bowman, Sabrina Spencer, Kristi Anseth, University of Colorado Boulder, Boulder, CO, USA

  • 1:30:00 PM 43. Photoinduced Hydrogel Network Reorganization Modulates Intestinal Organoid Shape To Direct Fate Specification, Max Yavitt(1,2)*, Michael Blatchley, PhD(1,2), Peter Dempsey, PhD(3), Kristi Anseth, PhD(1,2); (1)University of Colorado Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA, (3)University of Colorado Anschutz Medical Campus, Aurora, CO, USA

  • 1:45:00 PM 44. Advances in Replacement of Sutures and Surgical Glues by Switchable Electroadhesion of Polyelectrolyte Hydrogel to Animal Tissue, Leah Borden*, Srinivasa Raghavan, PhD, University of Maryland College Park, College Park, MD, USA

  • 2:00:00 PM 45. An Ultrasound-Responsive, Spatiotemporally-Controlled Biomaterial Platform for In-vitro Modeling of Breast Cancer Progression, Katherine Huynh, B.S.*, Kylene Lowrey, BS, Sara Evans-Dutson, BS, Mithila Handu, PhD, Sean Speese, PhD, Carolyn Schutt, PhD, Oregon Health and Science University, Portland, OR, USA

  • 2:15:00 PM 46. Strain-stiffening Zwitterionic Hydrogels, SONU KIZHAKKEPURA, PhD(1)*, Le Zhou(1), John Klier, PhD(2), Todd Emrick, PhD(1), Shelly Peyton, PhD(1); (1)University of Massachusetts Amherst, Amherst, MA, USA (2)University of Oklahoma, Norman, OK, USA